Canon 50D vs Nikon D800E: A Hands-On Comparative Deep Dive for Enthusiasts and Professionals

In my fifteen-plus years as a camera reviewer, I’ve often found that comparing cameras separated not just by manufacturer but by era can be a revealing exercise in understanding evolution and user priorities. Today, I’m taking an in-depth look at two advanced DSLRs - Canon's 50D, launched in 2008 as a strong successor to the 40D, and Nikon’s D800E, a 2012 full-frame powerhouse known for its ultra-high resolution. These cameras come from distinct design philosophies, with the 50D targeting advanced enthusiasts and the D800E aimed squarely at professionals demanding ultimate image quality.

Having tested both extensively in varied conditions - portrait studios, sprawling landscapes, fast-paced wildlife shoots, high-intensity courtside action, and hands-on street sessions - I’ll guide you through their strengths and weaknesses, providing practical, user-centric advice that goes well beyond spec sheets. Whether you already own lenses from Canon EF/EF-S or Nikon F mounts, or are simply researching your next DSLR, this comparison aims to equip you with nuanced insights to find the right fit for your photography style and budget.

A Matter of Size and Handling: Ergonomics at First Touch

When picking up the Canon 50D and the Nikon D800E, the first thing that strikes me is their roughly similar footprint but discernibly different proportions. Both are “mid-size” SLR bodies but while the Canon feels slightly sleeker and somewhat lighter at 822g compared to Nikon's 900g, the D800E impresses with a more substantial grip and a taller body depth.

The Canon's dimensions (146 x 108 x 74mm) make it easier to carry for extended periods - ideal for travel or street photography. The Nikon (146 x 123 x 82mm) feels rock-solid in hand, with robust construction and more thoughtful weight distribution. If you handhold your camera all day or routinely balance heavy telephoto lenses (especially Nikon’s extensive F-mount lineup), the increased bulk may be an advantage rather than a drawback.

Ergonomically, both cameras feature traditional DSLR controls, but as I explored more, their layouts and accessibility varied in meaningful ways.

Control Layout: Where Experience Meets Intuition

Peering down at their top control panels, the Canon 50D employs a clean, minimalist approach - a mode dial on the left and the main control dial close to the shutter button on the right. This lets me dial in exposure quickly without shifting grip. Exposure compensation and ISO adjustments are straightforward through dedicated buttons, though some require the rear dial and button combination for access.

The Nikon D800E follows Nikon’s characteristic control-heavy layout, boasting 51 autofocus points and multiple customizable buttons. The dual control dials allow faster exposure tweaks mid-action, critical for professional sports or wildlife shooters. I found Nikon’s top-panel layout demanded a slightly longer learning curve but rewarded me with operational efficiency once mastered.

Both cameras feature pop-up flashes; the Canon’s built-in flash has a slightly longer published range (13 meters vs Nikon’s 12 meters at ISO 100), but for anything beyond fill light, external flash units remain essential.

Sensor and Image Quality: The Heart of the Matter

A major defining difference jumps out immediately: sensor size and resolution. The 50D sports an APS-C sensor measuring 22.3 x 14.9mm, while the D800E has a full-frame sensor at 35.9 x 24mm - more than double the sensor area.

The 50D’s 15-megapixel sensor, utilizing Canon’s DIGIC 4 processor, was state-of-the-art in 2008, delivering respectable image quality with an ISO range of 100-3200 (expandable to 12800). However, compared to the Nikon’s massive 36.3-megapixel sensor coupled with Expeed 3 processing, the 50D naturally falls behind in dynamic range, detail, and high-ISO performance.

Nikon's D800E notably removes the standard anti-aliasing filter to maximize resolving power. This choice enhances sharpness tremendously, making the camera a favorite for landscape, studio, and macro photographers seeking unparalleled detail. The tradeoff is increased susceptibility to moiré patterns in certain patterns, but for many pros, the gain outweighs the risk.

DxOMark scores reinforce these impressions: the D800E’s overall rating sits at 96 versus the 50D’s 63, with significant gaps in color depth (25.6 vs 21.8 bits), dynamic range (14.3 vs 11.4 EV), and low-light ISO scores (2979 vs 696). Practically, this means the Nikon delivers cleaner images in shadows and high-contrast scenes with less noise - crucial for genres like night and astro photography.

Chasing the Action: Autofocus and Burst Shooting

Speed and precision of autofocus and continuous shooting are essential for wildlife, sports, and street pros. Although the 50D was groundbreaking in the APS-C class for its nine-point AF system with face detection, it lacks sophisticated tracking systems. My experience revealed it performs well for casual sports and portraits but struggles with erratic or fast-moving subjects due to limited autofocus points and no dedicated tracking AF.

By contrast, the Nikon D800E sports 51 AF points, including 15 cross-type sensors, phase-detection focusing, and face detection with tracking - features honed for demanding studio and action scenarios. Its AF system handled bird flights, tennis matches, and even running children with notable speed and confidence during my sessions.

Where the Canon gains out is burst shooting speed at 6.3 fps, respectable even now. However, the Nikon’s 4 fps maximum continuous shooting might seem underwhelming, yet it balances speed with an enormous 36MP per file, demanding more processing power and buffer space. For action photographers requiring faster frame rates, the 50D may tempt on price and speed, but the Nikon compensates with superior tracking and autofocus reliability.

Composing and Reviewing Shots: Screens and Viewfinders

Lounging under natural light or working indoors, I found the Canon’s fixed 3-inch TFT LCD respectable in resolution (920k pixels) but limited in viewing angle and brightness. The Nikon’s 3.2-inch screen offers a marginal resolution bump and a wider 170° viewing angle, providing excellent off-angle usability - handy for low shooting positions or bright conditions.

Both use optical pentaprism viewfinders - Canon provides 95% frame coverage at 0.6x magnification, while Nikon boasts 100% coverage at 0.7x. The full-frame coverage and larger viewfinder magnification on the D800E lend greater confidence during composition, which I personally appreciate when framing landscapes or architectural subjects critically.

Although neither camera boasts touchscreens or high-resolution electronic viewfinders found on newer mirrorless models, their analog optical systems remain dependable in all lighting.

In the Field: Build Quality and Environmental Resilience

Both cameras are built to withstand professional rigor, but their sealing and weight hint at subtle differences.

The Canon 50D incorporates partial weather sealing appropriate for moderate moisture or dusty conditions, ideal for enthusiasts tackling diverse environments. The Nikon D800E, designed for professional use, has more robust environmental sealing though neither is fully waterproof or shockproof.

Weight differences are minor but noticeable during long hikes or multi-hour shoots; the 50D’s lighter frame offers ergonomic comfort, while the D800E’s heft conveys reassurance of durability and high-end build.

The Lens Ecosystem and Mount Compatibility

Canon's EF and EF-S mount system for the 50D supports over 326 native lenses, spanning affordable primes to L-series telephotos. For users invested in Canon glass, the 50D ensures excellent compatibility and access to innovations like ultrasonic motors that improve autofocus speed.

Nikon’s F-mount, used on the D800E, is one of the deepest and most diverse systems available, with over 300 lenses as well. Its full-frame sensor can take full advantage of FX format lenses, unlocking stunning image quality from primes, tilt-shifts, macros, and extensive telephotos.

Both mounts support manual focusing, which I often rely on for macro work and studio portraits.

Powering Your Passions: Battery and Storage Considerations

Battery life on both cameras exceeded expectations in my real-world use. The Canon 50D’s BP-511A battery offers about 800 shots per charge - a solid figure for enthusiast shooters. The D800E’s EN-EL15 battery improves on this with approximately 900 shots, factoring in more processor-intensive capture due to the higher resolution sensor.

Storage-wise, the 50D uses a single Compact Flash (CF) slot supporting UDMA, while the D800E adds flexibility with dual slots - one CF and one SD/SDHC/SDXC UHS-I. This dual-slot approach is a boon for professionals needing instant backups or segregating JPEGs and RAW files.

Video Capabilities: A Tale of Two Eras

Although video wasn't a primary feature in the 50D, it offers no video recording functions - typical for cameras from 2008 focusing on still image excellence.

The D800E supports full HD video (up to 1080p at 30fps) with multiple frame rate options and professional codecs (MPEG-4, H.264). With microphone and headphone ports, it serves well for videographers needing manual audio control.

For hybrid shooters considering video, the Nikon clearly advances capabilities, albeit not matching modern mirrorless video offerings.

Practical Performance per Photography Genre

Let’s break down usage across common photography disciplines based on my testing:

Portrait Photography

The D800E’s 36MP sensor and larger dynamic range beautifully render skin tones with nuance and smooth tonal transitions. Its 51-point AF with face detection enables sharp eyes and flawless focus tracking for expressions.

The 50D performs well in controlled lighting but struggles with noisy shadows and limited bokeh depth due to APS-C factors. Its face detection is basic but adequate for casual portraiture.

Landscape Photography

The D800E reigns supreme with ultra-high resolution, wide dynamic range, and superior detail retention - ingredients for wall-sized prints. Weather sealing grants confidence in variable outdoor conditions.

The 50D lags in resolution and dynamic range but remains a cost-effective option for amateurs exploring landscapes.

Wildlife Photography

The Nikon’s advanced AF tracking and precise focus are essential for unpredictable wildlife. The 4 fps rate is moderate but fine for methodical shooting.

The Canon’s faster burst rate helps but is handicapped by limited AF points, making it less reliable for continuous focus on fast targets.

Sports Photography

Sports shooters will appreciate the Nikon’s tracking and frame coverage more than the 50D’s quicker frame rates. Nikon’s autofocus reliability under low light impresses.

The 50D suits entry-level sports imaging with decent speed but may frustrate serious shooters.

Street Photography

Size and discretion favor the Canon 50D with lighter weight and simpler controls. Its noise at higher ISO is manageable.

The D800E’s larger body and louder shutter may draw attention. However, its image quality leads to striking street captures when discretion is less critical.

Macro Photography

Both cameras lack specialized macro modes, but the D800E’s resolution reveals extraordinary detail. Precision manual focus and compatibility with macro lenses excel here.

The 50D performs admirably for beginners or casual macro enthusiasts.

Night and Astro Photography

Nikon’s better high ISO prowess and long exposure capabilities make it the uncontested choice, delivering low noise and huge dynamic range.

The 50D is limited by its sensor but can still capture star trails and night scenes with moderate ISO and post-processing.

Travel Photography

The Canon 50D’s lighter frame, efficient battery, and reliable performance make it travel-friendly.

The Nikon’s larger size means extra weight but rewards with unmatched image quality and versatility for serious travelers.

Professional Workflows

D800E’s dual card slots, extensive file format support, and robust build suit rigorous professional environments and fast-paced studios.

The Canon 50D, older technology-wise, serves well in casual or budget-conscious professional settings but won't rival modern workflow integration.

Canon 50D screen back Nikon D800E front Nikon D800E screen back

My Real-Life Picture Gallery: Side-by-Side Image Insights

Through extensive shoots, I consistently observed the D800E delivering ultra-detailed images with vibrant color fidelity, excellent tonal gradation, and precise sharpness - ideal for clients demanding print-quality results.

The Canon 50D images remain pleasant and punchy at modest sizes, with respectable clarity but less room for aggressive cropping or tonal recovery.

Summary Ratings and Value Assessment

So, Which Should You Choose?

Choosing between these two cameras boils down to your priorities, budget, and pre-existing gear.

1. For Enthusiast Hobbyists and Budget-Conscious Shooters:
   The Canon 50D represents a reliable, affordable gateway into advanced DSLR photography. Its agile burst speed, respectable image quality, and solid build support varied shooting styles - portraits, street, travel, and casual sports. If you already own Canon lenses or want a durable camera without breaking the bank, the 50D remains a compelling choice despite its age.

2. For Professionals and Serious Enthusiasts Seeking Ultimate Image Quality:
   The Nikon D800E stands out for landscape, studio, wildlife, and night photography where detail, dynamic range, and autofocus accuracy are non-negotiable. Its higher price tag corresponds to technical superiority that will serve a pro’s workflow and creative demands for years to come. If video capability and dual card slots are important, this camera offers a well-rounded package.

3. Crossover Users:
   If you shoot a mix - traveling with street and landscapes, but occasionally aiming for portraits or wildlife - the Nikon delivers superior overall optical quality and features but demands handling heavier gear and investing in top-tier lenses. The Canon 50D provides lighter convenience but with technical compromises.

Final Thoughts from My Experience Behind the Viewfinder

Having placed these two DSLRs side-by-side in my studio and in the wild, I appreciate each for what it offers. The Canon 50D feels like a dependable, passionate craftsman’s tool, versatile and engaging. The Nikon D800E, on the other hand, is the quintessential fine-art instrument: precise, formidable, and uncompromising.

Neither camera is “perfect” by modern standards - both lack features like touchscreen interfaces, in-body stabilization, or wireless connectivity that mirrorless contemporaries provide. Yet their strengths remain relevant, especially for photographers valuing optical excellence, tactile operation, and solid mechanical build.

If affordability matters most, consider the Canon 50D. If uncompromising image integrity is your obsession, and budget allows, the Nikon D800E will reward you richly.

Whichever path you choose, these cameras embody milestones in DSLR history - timeless workhorses with stories yet to tell. I hope my experiences help you write your own.

If you have questions on lens choices, accessories, or real-world shooting tips with either body, feel free to ask - I’m here to help you make the best informed decision for your creative journey.